Product Name |
CAPTISOL |
Chemical / Trade Name |
Sulfobutyl ether betacyclodextrin |
Description |
Captisol® is a patent protected, uniquely modified cyclodextrin, whose chemical structure was rationally designed to maximize safety and optimize interaction to improve the solubility, stability, bioavailability or lessen volatility, irritation, smell or taste.
Captisol® is a polyanionic beta-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether (SBE). Captisol® is not a single chemical species, but comprised of a multitude of polymeric structures of varying degrees of substitution and positional/regional isomers dictated and controlled to a uniform pattern by a patented manufacturing process consistently practiced and improved to control impurities.
The selection of Captisol® and its desirable safety profile and drug solubilization properties was based upon extensive evaluations of the mono, tetra and hepta-substituted dominated compositions. Captisol® is the trade name for Ligand's modified beta-cyclodextrin technology.
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Product Application |
- Improve solubility of water-insoluble APIs in all dosage forms
- Improved Compatibility, Stability, bio availability
- Permits lower dosing of APIs (i.e. potential for dose sparing)
- Shelter the API from oxidative and hydrolytic degradation
- Taste masking in oral, nasal and inhalation preparations
- Reduction of irritation at site of injection in injectable formulas (parenteral)
- Potential to enable faster acting versions of many currently approved oral products.
- Captisol® is safe when administered parenterally or orally and does not exhibit the nephrotoxicity associated with beta-cyclodextrin.
- Simplified preparation process, eliminating the need for refrigeration for some commercial products.
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Molecule specific |
Voriconazole/ Aripiprazole/ Amiodarone HCL/ Carphilzomib/ Posaconazole/ Ziprasidone/ Melphalan/ Carbamazepine/ Delafloxacin/ Topiramate/ Clopidogrel/ Docetaxel/ Meloxicam/ Tigecyclin
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Regulatory |
USDMF
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Packing |
Customized Packaging is available |