Pharmaceuticals

Solubility Enhancer

  • Product Name SEPITRAP 80
    Chemical / Trade Name POLYSORBATE 80 / MAGNESIUM ALUMINIUM SILICATE
    Description POLYSORBATE 80 IN DRY POWDER FORM
    Product Application SOLUBILIZER IN POWDER FORM DIRECTLY COMPRESSIBLE
    Molecule specific
    Regulatory USP,EP,JP & US-DMF
    Packing 25 KGS
  • Product Name SEPITRAP 4000
    Chemical / Trade Name POLYOXYL 40 HYDROGENATED CASTOR OIL/MAGNESIUM ALUMINIUM SILICATE
    Description POLYOXYL 40 HYDROGENATED CASTOR OIL IN DRY POWDER FORM
    Product Application SOLUBILIZER IN POWDER FORM DIRECTLY COMPRESSIBLE
    Molecule specific
    Regulatory USP,EP,JP & US-DMF
    Packing 25 KGS
  • Product Name CAPTISOL
    Chemical / Trade Name Sulfobutyl ether betacyclodextrin
    Description Captisol® is a patent protected, uniquely modified cyclodextrin, whose chemical structure was rationally designed to maximize safety and optimize interaction to improve the solubility, stability, bioavailability or lessen volatility, irritation, smell or taste.

    Captisol® is a polyanionic beta-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether (SBE). Captisol® is not a single chemical species, but comprised of a multitude of polymeric structures of varying degrees of substitution and positional/regional isomers dictated and controlled to a uniform pattern by a patented manufacturing process consistently practiced and improved to control impurities.

    The selection of Captisol® and its desirable safety profile and drug solubilization properties was based upon extensive evaluations of the mono, tetra and hepta-substituted dominated compositions. Captisol® is the trade name for Ligand's modified beta-cyclodextrin technology.
    Product Application
    • Improve solubility of water-insoluble APIs in all dosage forms
    • Improved Compatibility, Stability, bio availability
    • Permits lower dosing of APIs (i.e. potential for dose sparing)
    • Shelter the API from oxidative and hydrolytic degradation
    • Taste masking in oral, nasal and inhalation preparations
    • Reduction of irritation at site of injection in injectable formulas (parenteral)
    • Potential to enable faster acting versions of many currently approved oral products.
    • Captisol® is safe when administered parenterally or orally and does not exhibit the nephrotoxicity associated with beta-cyclodextrin.
    • Simplified preparation process, eliminating the need for refrigeration for some commercial products.
    Molecule specific Voriconazole/ Aripiprazole/ Amiodarone HCL/ Carphilzomib/ Posaconazole/ Ziprasidone/ Melphalan/ Carbamazepine/ Delafloxacin/ Topiramate/ Clopidogrel/ Docetaxel/ Meloxicam/ Tigecyclin
    Regulatory USDMF
    Packing Customized Packaging is available